A new, simple and sensitive spectrophotometric method for the detn. of some sulfonamide drugs was developed. The method is based on the diazotization of sulfacetamide, sulfadiazine, sulfaguanidine, sulfamerazine, sulfamethazine, sulfamethoxazole, and their coupling with 8-hydroxyquinoline in alk. media to yield red colored products with absorption maxima at 500 nm. Beer's law was obeyed from 0.1-7.0 μg mL-1. The limits of quantification and limits of detection were 0.11-0.18 and 0.03-0.05 μg mL-1, resp. Intraday precision (RSD 0.1-0.5%) and accuracy (recovery 97.3-100.8%) of the developed method were evaluated. No interference was obsd. from common adjuvants. The method was successfully applied to the assay of sulfa drugs in pharmaceutical formulations. [on SciFinder(R)]
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